ChemicalBook CAS DataBase List 7-formylheptanoic acid

7-formylheptanoic acid synthesis

10synthesis methods

Product Name:7-formylheptanoic acid
CAS Number:929-48-6
Molecular formula:C8H14O3
Molecular Weight:158.2

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Yield: 86%

Reaction Conditions:

with 2-iodoxybenzoic acid in dimethyl sulfoxide for 4 h;Inert atmosphere;

Steps:

General Procedure for Oxidation of ω-Hydroxyacids to ω-Oxoacids
General procedure: IBX (1.5 eq) was added to a solution of the hydroxyacid (2 mmol) in DMSO(7 mL). The mixture was stirred for 4 h and quenched by addition of water. The precipitate was removed by filtration. Extraction with ethyl acetate (2 × 50 ml),anhydrification with Na2SO4, and removal of the solvent in vacuo gave almost pureoxoacid as colorless oil.

References:

Rajabi, Mehdi;Lanfranchi, Moreno;Campo, Federica;Panza, Luigi [Synthetic Communications,2014,vol. 44,# 8,p. 1149 - 1154] Location in patent:supporting information