7-hydroxyisoquinoline-4-carboxylic acid synthesis

Yield:-

Reaction Conditions:

with water;hydrogen bromide;acetic acid at 130; for 3 h;

Steps:

93.93.1

7-Methoxy-isoquinoline-4-carboxylic acid (2.5 g, 12.3 mMol) is dissolved in HBr/HOAc (33% wt; 10 mL) and H₂O (0.5 mL) is added. The reaction mixture is warmed to 130 ⁰C in a sealed tube.After 3 h it is allowed to cool to ambient temperature. All volatiles are removed under reduced pressure and the remaining crude product is used without further purification for the next step.

References:

WO2007/31265,2007,A2 Location in patent:Page/Page column 60