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ChemicalBook CAS DataBase List 7-Methylpyrazolo[1,5-a]pyriMidin-5(4H)-one
29269-60-1

7-Methylpyrazolo[1,5-a]pyriMidin-5(4H)-one synthesis

1synthesis methods
1820-80-0 Synthesis
3-Aminopyrazole

1820-80-0
476 suppliers
$5.00/5g

4341-76-8 Synthesis
Ethyl 2-butynoate

4341-76-8
229 suppliers
$10.00/1g

-

Yield:29269-60-1 50%

Reaction Conditions:

Stage #1: 3-aminopyrazole;Ethyl 2-butynoate in 1,4-dioxane at 110; for 2 h;Microwave irradiation;Inert atmosphere;Michael Addition;
Stage #2: with sodium methylate in 1,4-dioxane at 20; for 12 h;Microwave irradiation;Inert atmosphere;Michael Addition;

References:

Jismy, Badr;Guillaumet, Gérald;Allouchi, Hassan;Akssira, Mohamed;Abarbri, Mohamed [European Journal of Organic Chemistry,2017,vol. 2017,# 41,p. 6168 - 6178]