7-(trifluoroMethyl)isoquinolin-1(2H)-one synthesis
- Product Name:7-(trifluoroMethyl)isoquinolin-1(2H)-one
- CAS Number:410086-28-1
- Molecular formula:C10H6F3NO
- Molecular Weight:213.16
455-19-6
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410086-28-1
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Yield:-
Steps:
Multi-step reaction with 4 steps
1.1: piperidine; pyridine / 0.33 h / 20 - 105 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 75 °C / Inert atmosphere
3.1: sodium azide / 1,4-dioxane; water / 0.33 h / 0 °C / Inert atmosphere
4.1: diphenylether; dichloromethane / 260 °C
References:
WO2012/35078,2012,A1