cis-3-[4-(1,1-DiMethylheptyl)-2-(phenylMethoxy)phenyl]-cyclohexanol synthesis
- Product Name:cis-3-[4-(1,1-DiMethylheptyl)-2-(phenylMethoxy)phenyl]-cyclohexanol
- CAS Number:70434-49-0
- Molecular formula:C28H40O2
- Molecular Weight:408.62
70120-09-1
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Yield:-
Steps:
Multi-step reaction with 7 steps
1: 57 percent / DMSO, NaOH / 4 h / 15 °C
2: 78 percent / H2 / 10percent Pd/C / ethanol / 13 h / 2585.7 Torr
3: 100 percent / Br2 / CCl4 / 0.25 h / 30 °C
4: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
5: Mg / tetrahydrofuran / 20 h / Heating
6: CuI / tetrahydrofuran / 0.5 h / -3 °C
7: 51 percent / NaBH4 / methanol; tetrahydrofuran / 1 h / -40 °C
References:
Melvin, Lawrence S.;Johnson, M. Ross;Harbert, Charles A.;Milne, George M.;Weissman, Albert [Journal of Medicinal Chemistry,1984,vol. 27,# 1,p. 67 - 71]
![3-[4-(1,1-DiMethylheptyl)-2-(phenylMethoxy)phenyl]cyclohexanone](/CAS/GIF/70434-13-8.gif)
![Cyclohexanol, 3-[4-(1,1-dimethylheptyl)-2-(phenylmethoxy)phenyl]-, trans- (9CI)](/CAS/20210305/GIF/70434-50-3.gif)
70120-08-0
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70120-10-4
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21406-61-1
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