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(s)-1-benzyl-2-methyl-4,4-difluoropyrrolidine-1,2-dicarb synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: diethyl ether / 0 °C
2: (diethylamido)sulfur trifluoride (DAST) / CH2Cl2 / 16 h / Ambient temperature

References:

Karanewsky;Badia;Cushman;DeForrest;Dejneka;Lee;Loots;Petrillo [Journal of Medicinal Chemistry,1990,vol. 33,# 5,p. 1459 - 1469]