3-(CHLOROMETHYL)-5-(4-CHLOROPHENYL)-1,2,4-OXADIAZOLE synthesis
- Product Name:3-(CHLOROMETHYL)-5-(4-CHLOROPHENYL)-1,2,4-OXADIAZOLE
- CAS Number:73217-30-8
- Molecular formula:C9H6Cl2N2O
- Molecular Weight:229.06
3272-96-6
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$85.00/250mg
122-01-0
384 suppliers
$13.00/25g
73217-30-8
27 suppliers
$90.00/100mg
Yield:-
Reaction Conditions:
with sodium hydrogencarbonate in hexane;water;ethyl acetate;acetone;toluene;
Steps:
10 3-Chloromethyl-5-(4-chlorophenyl)-1,2,4-oxadiazole
PREPARATION 10 3-Chloromethyl-5-(4-chlorophenyl)-1,2,4-oxadiazole A solution of 2-chloroacetamidoxime (0.5 g) and sodium bicarbonate (0.78 g) in 10 mL of anhydrous acetone was treated with 4-chlorobenzoyl chloride (0.58 mL) at room temperature for 2 hours, concentrated in vacuo, dissolved in water and extracted with ethyl acetate. The organic layers were combined, dried with MgSO4 and concentrated to a semi-solid. This material was redissolved in toluene (50 mL). refluxed under nitrogen for 15 hours, cooled and absorbed on to silica gel. Chromatography using ethyl acetate:hexane (1:9) gave the pure title product as a light yellow solid, mp 79-80° C. Mass spectrum m/e: 228 (M+), 1 H NMR (250 MHz, CDCl3) δ 8.1 (d, 2H), 7.5 (d, 2H), 4.7 (s, 2H).
References:
US6166020,2000,A
122-01-0
384 suppliers
$13.00/25g
73217-30-8
27 suppliers
$90.00/100mg
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73217-30-8
27 suppliers
$90.00/100mg
122-01-0
384 suppliers
$13.00/25g
3272-96-6
34 suppliers
$85.00/250mg
73217-30-8
27 suppliers
$90.00/100mg