6-Quinazolinecarboxylicacid,2-amino-1,4-dihydro-4-oxo-(9CI) synthesis
- Product Name:6-Quinazolinecarboxylicacid,2-amino-1,4-dihydro-4-oxo-(9CI)
- CAS Number:741617-89-0
- Molecular formula:C9H7N3O3
- Molecular Weight:205.1702
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Yield:741617-89-0 70%
Reaction Conditions:
Stage #1: methyl 2-amino-4-oxo-3,4-dihydroquinazoline-6-carboxylatewith sodium hydroxide;water at 75; for 12 h;
Stage #2: with hydrogenchloride in water;
Steps:
3
2-Amino-4-oxo-3,4-dihydro-quinazoline-6-carboxylic acid: A suspension of 2-Amino-4- oxo-3,4-dihydro-quinazoline-6-carboxylic acid methyl ester (1.3 g, 0.006 mol) in NaOH/water (1 :1) was refluxed at 750C for 12 h. The reaction mixture was rotoevaporated and residue neutralized withl.5N HCl. The resultant precipitate was filtered to obtain 6 as white solid. Yield: 70 % (0.85 g).
References:
WO2008/152142,2008,A1 Location in patent:Page/Page column 26
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