Hydrazine Carboxamide,N-{4-[4(4-methoxyphenyl)-1-pipezinyl]phenyl} synthesis
- Product Name:Hydrazine Carboxamide,N-{4-[4(4-methoxyphenyl)-1-pipezinyl]phenyl}
- CAS Number:74852-89-4
- Molecular formula:C18H23N5O2
- Molecular Weight:341.41
![4-([4-(4-METHYLOXY-PHENYL)-PIPERAZIN-1-YL]-PHENYL)-CARBAMIC ACID PHENYL ESTER](/CAS/GIF/74853-06-8.gif)
74853-06-8
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$779.63/250MG
74852-89-4
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Yield:74852-89-4 100%
Reaction Conditions:
with hydrazine hydrate monohydrate for 3 h;Reflux;
Steps:
1
[0072] Reduction of the nitro functionality in 5 via palladium-catalyzed transfer hydrogenation with hydrazine monohydrate provided the aniline, which was converted to triazo lone 9 through the well-characterized phenylcarbamate and semicarbazide intermediates (Scheme 2). Alkylation of the triazo lone amine with 2-bromobutane followed by removal of the methyl moiety afforded phenol 11. Base-catalyzed displacement of the tosyl moiety in 4 by the phenol provided the final des-triazole Analogue 1.
References:
WO2015/116947,2015,A1 Location in patent:Page/Page column 0072
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38212-30-5
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