2-chloro-9,10-dimethoxy-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one synthesis
- Product Name:2-chloro-9,10-dimethoxy-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
- CAS Number:75535-96-5
- Molecular formula:C14H13ClN2O3
- Molecular Weight:292.72
![9,10-dimethoxy-6,7-dihydropyrimido[6,1-a]isoquinoline-2,4-dione](/CAS/20180723/GIF/68619-18-1.gif)
68619-18-1
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75535-96-5
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Yield:-
Reaction Conditions:
with sodium hydroxide;trichlorophosphate
Steps:
7 9,10-Dimethoxy-2-chloro-6,7-dihydro-4H-pyrimido(6,1-a)isoquinolin-4-one
EXAMPLE 7 9,10-Dimethoxy-2-chloro-6,7-dihydro-4H-pyrimido(6,1-a)isoquinolin-4-one A mixture of 30.0 g of 9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimido(6,1-a)isoquinolin-2,4-dione and 300 ml of phosphorus oxychloride is heated on a steam bath for 4 hours. The excess of phosphorus oxychloride is distilled under reduced pressure. The residue is poured into a cold solution of sodium hydroxide. A yellow solid precipitates which is collected by filtration. The product is purified by passage through a silica gel column using chloroform as eluent. Yield 28.0 g, m.p. 235°-236° C.
References:
US4482556,1984,A
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