Butanoic acid, 4-bromo-2-(hydroxyimino)-3-oxo-, ethyl ester synthesis
- Product Name:Butanoic acid, 4-bromo-2-(hydroxyimino)-3-oxo-, ethyl ester
- CAS Number:75689-07-5
- Molecular formula:C6H8BrNO4
- Molecular Weight:238.04
13176-46-0
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Yield:75689-07-5 88%
Reaction Conditions:
with acetic acid;sodium nitrite in water at 20; for 2 h;
Steps:
121A.2
2.16 g (31.6 mmol) of sodium nitrite, dissolved in 20 ml of water, were added to a solution, stirred at 0° C., of 6.0 g (28.7 mmol) of ethyl 4-bromo-3-oxobutanoate in 40 ml of acetic acid. The reaction mixture was then stirred at room temperature for 2 h. After addition of water, the mixture was extracted twice with diethyl ether. The combined organic phases were washed with water and saturated aqueous sodium chloride solution. Drying over sodium sulphate and removal of the solvent gave 6.0 g (88% of theory) of the intermediate ethyl 4-bromo-2-(hydroximino)-3-oxobutanoate as a colourless liquid.
References:
TW2016/5831,2016,A Location in patent:Paragraph 0211
5408-04-8
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141-97-9
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