
3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)- synthesis
- Product Name:3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)-
- CAS Number:76272-36-1
- Molecular formula:C14H20N2
- Molecular Weight:216.33

76272-34-9
![3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)-](/CAS/GIF/76272-36-1.gif)
76272-36-1
General procedure for the synthesis of exo-8-benzyl-8-azabicyclo[3.2.1]octan-3-one oxime from 8-benzyl-8-azabicyclo[3.2.1]octan-3-amine:[105] 8-benzyl-8-azabicyclo[3.2.1]octan-3-one oxime (7.65 g, 33 mmol) was dissolved in 1-pentanol (130 mL) at 120 °C. Sodium metal (7.6 g, 0.33 mol, 10.0 eq.) was added in batches over 2 hours. The mixture was stirred and heated under reflux conditions for 5 hours, then cooled to 5°C. The reaction mixture was slowly acidified with 6 M HCl until the pH reached acidic, and then the aqueous phase was further extracted with 6 M HCl (3 x 100 mL). The aqueous layer was gradually alkalized to pH 10 by addition of 5 M NaOH. the resulting aqueous solution was extracted with EtOAc (3 × 100 mL). The organic extracts were combined, dried with MgSO4, filtered and concentrated in vacuum. The crude product was purified by column chromatography (5-10% MeOH/CH2Cl2) to afford pure exo-8-benzyl-8-azabicyclo[3.2.1]octan-3-amine as a solid (2.60 g, 36%).

542-05-2
498 suppliers
$6.00/10g
![3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)-](/CAS/GIF/76272-36-1.gif)
76272-36-1
81 suppliers
$42.40/1mg:
Yield:-
Steps:
Multi-step reaction with 3 steps
1.1: hydrogenchloride; water / 1 h / Reflux
1.2: 6 h / 0 - 50 °C
1.3: pH 12
2.1: hydroxylamine hydrochloride; pyridine / ethanol / 18 h / Reflux
3.1: sodium; pentan-1-ol / 2 h / Reflux
References:
SHANGHAI TARGETDRUG CO., LTD.;SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES US2011/251192, 2011, A1

76272-34-9
48 suppliers
$140.00/50 mg
![3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)-](/CAS/GIF/76272-36-1.gif)
76272-36-1
81 suppliers
$42.40/1mg:

76272-34-9
48 suppliers
$140.00/50 mg
![3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)-](/CAS/GIF/76272-36-1.gif)
76272-36-1
81 suppliers
$42.40/1mg:
![8-Azabicyclo[3.2.1]octan-3-one, 8-methyl-, oxime](/CAS/20180601/GIF/1515-26-0.gif)
1515-26-0
5 suppliers
inquiry
![3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)-](/CAS/GIF/76272-36-1.gif)
76272-36-1
81 suppliers
$42.40/1mg:
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
0 suppliers
inquiry
![3-AMINO-8-BENZYL-8-AZABICYCLO[3.2.1]OCTANE (3-EXO)-](/CAS/GIF/76272-36-1.gif)
76272-36-1
81 suppliers
$42.40/1mg: