N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE synthesis
- Product Name:N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE
- CAS Number:76362-28-2
- Molecular formula:C14H17N5O2
- Molecular Weight:287.3171
Yield:76362-28-2 92%
Reaction Conditions:
with toluene-4-sulfonic acid in butan-1-ol; for 3 h;Heating / reflux;
Steps:
1.I.A
A) Preparation of 3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]- propanenitrile (IV); A mixture of 4-amino-2-chloro-6,7-dimethoxyquinazoline (50 g, 0.208 mol), 3- methylaminopropionitrile (35.07 g, 0.416 mol) and jp-toluenesulphonic acid (39.71 g, 0.208 mol) was heated to reflux in 1-butanol (350 ml) for 3 hr. The reaction mass was concentrated at 70-80°C under reduced pressure. The resulting concentrated mass was stirred with aqueous ethanol (50% v/v, 250 ml) and pH of the mixture was adjusted to 10.0 to 10.5. Thereafter, the precipitate was filtered and dried at 60-65°C under vacuum
References:
WO2007/74364,2007,A1 Location in patent:Page/Page column 7-8
