3-(tetrahydro-furan-3-yl)-propionic acid ethyl ester synthesis
- Product Name:3-(tetrahydro-furan-3-yl)-propionic acid ethyl ester
- CAS Number:766539-77-9
- Molecular formula:C9H16O3
- Molecular Weight:172.22
58963-70-5
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Yield:-
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in ethanol; for 6 h;
Steps:
109.b
b) Ethyl (E)-3-(3-furyl)prop-2-enoate (11.88 g, 71.50 mmol, 1 eq) was stirred under a hydrogen balloon in ethanol (150 ml) containing 10% palladium on charcoal (1.2 g) for 6 hours. The reaction was filtered to remove the palladium residues and evaporated under reduced pressure. NMR suggested product and over reduced product. The crude product was combined with the product from a smaller scale reaction and purified by column chromatography using a silica column and eluting with hexane then 0-20% ethyl acetate/hexane. Desired fractions were combined and evaporated to afford ethyl 3-(oxolan-3-yl)propanoate as a clear oil. (6.46 g).
References:
US2008/4302,2008,A1 Location in patent:Page/Page column 111
941687-62-3
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498-60-2
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$16.00/1g
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79710-86-4
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