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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 3-bromo-7-chlorothieno[3,2-b]pyridine-6-carbonitrile
798574-82-0

3-bromo-7-chlorothieno[3,2-b]pyridine-6-carbonitrile synthesis

4synthesis methods
700844-09-3 Synthesis
7-CHLOROTHIENO[3,2-B]PYRIDINE-6-CARBONITRILE

700844-09-3
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3-bromo-7-chlorothieno[3,2-b]pyridine-6-carbonitrile

798574-82-0
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Yield:-

Reaction Conditions:

with N-Bromosuccinimide in N-methyl-acetamide;(2S)-N-methyl-1-phenylpropan-2-amine hydrate;dichloromethane;

Steps:

R.25 3-Bromo-7-chlorothieno[3,2-b]pyridine-6-carbonitrile

REFERENCE EXAMPLE 25 3-Bromo-7-chlorothieno[3,2-b]pyridine-6-carbonitrile A mixture of 7-chlorothieno[3,2-b]pyridine-6-carbonitrile (100 mg, 0.51 mmol) and N-bromosuccinimide (118 mg, 0.66 mmol) in 0.63 mL of dimethylformamide is stirred at room temperature for 4 days. Additional N-bromosuccinimide (118 mgs) is added and the reaction mixture is heated at 40° C. for 17 hours. Additional N-bromosuccinimide (118 mgs) is added and the reaction mixture is heated at 40° C. for 24 hours. Additional N-bromosuccinimide (118 mgs) is added and the reaction mixture is heated at 60° C. for 24 hours. The mixture is cooled to room temperature and treated with ice water and neutralized with aqueous saturated sodium bicarbonate. The resultant solid is purified by flash column chromatography eluding with 10% hexane in dichloromethane to provide 35 mg of 3-bromo-7-chlorothieno[3,2-b]pyridine-6-carbonitrile as a white solid, mp 176-178° C.; 1H NMR (DMSO-d6) δ 8.79 (s, 1H), 9.23 (s, 1H); MS 272.9, 274.8. Analysis for C8H2BrClN2S: Calcd: C, 35.13; H, 0.74; N, 10.24. Found: C, 34.73; H, 0.93; N, 9.89.

References:

US2004/242883,2004,A1

7-CHLOROTHIENO[3,2-B]PYRIDINE-6-CARBOXYLIC ACID

83179-01-5
66 suppliers
$117.00/100mg

3-bromo-7-chlorothieno[3,2-b]pyridine-6-carbonitrile

798574-82-0
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References
7-CHLOROTHIENO[3,2-B]PYRIDINE-6-CARBOXYLIC ACID

90690-94-1
25 suppliers
$90.00/100mg

3-bromo-7-chlorothieno[3,2-b]pyridine-6-carbonitrile

798574-82-0
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References
7-CHLOROTHIENO[3,2-B]PYRIDINE-6-CARBOXAMIDE

700844-10-6
5 suppliers
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3-bromo-7-chlorothieno[3,2-b]pyridine-6-carbonitrile

798574-82-0
12 suppliers
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References