8-tert-butylchroman-4-one synthesis
- Product Name:8-tert-butylchroman-4-one
- CAS Number:23067-79-0
- Molecular formula:C13H16O2
- Molecular Weight:204.26
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Yield:23067-79-0 44%
Reaction Conditions:
in ethylene glycol; for 4 h;Reflux;
Steps:
4.3
Step 3: 8-(tert-Butyl)chroman-4-one (4c) The solution of compound 4b (0.5 g, 2.3 mmol) in anhydrous ethylene glycol (5 mL) was heated to reflux for 4 h. The reaction mixture was cooled, poured into water and extracted with Et2O twice. The organic layers were combined, washed with 1N sodium hydroxide and sat. ammonium carbonate sequentially, dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by CC (elute: PE) to give compound 4c (0.2 g, 44%) as an oil.
References:
EP2511263,2012,A1 Location in patent:Page/Page column 26
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