(2S,3R)-1-(Dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-ol synthesis
- Product Name:(2S,3R)-1-(Dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-ol
- CAS Number:809282-20-0
- Molecular formula:C15H25NO2
- Molecular Weight:251.36
850222-40-1
106 suppliers
$75.00/100mg
925-90-6
340 suppliers
$12.00/5ml
809282-20-0
60 suppliers
$174.06/250mg
Yield:809282-20-0 99%
Reaction Conditions:
Stage #1: (2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone;ethylmagnesium bromide in tetrahydrofuran at 15; for 4 h;Grignard Reaction;
Stage #2: with ammonium bisulphate;water in tetrahydrofuran at 5;Product distribution / selectivity;
Steps:
a.2
2. (S)-3-(Dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1-one (774.6 g, 3.5 mol, ee 95 %) was dissolved in dry tetrahydrofuran (800 mL) in a 10 L double jacket vessel equipped with an electrical impeller stirrer, a gas transition line, PtIOO temperature measuring equipment and an oil based cooling/heating system and ethyl magnesium bromide (2 L, 2 M in THF) was added at a temperature of 15 °C within 2
References:
WO2008/12047,2008,A1 Location in patent:Page/Page column 20-21
850222-40-1
106 suppliers
$75.00/100mg
809282-20-0
60 suppliers
$174.06/250mg
850222-40-1
106 suppliers
$75.00/100mg
2386-64-3
206 suppliers
$45.00/5ml
809282-20-0
60 suppliers
$174.06/250mg