Labetalol Hydrochloride Impurity 19（(R,S)-Labetalol Hydrochloride） synthesis
- Product Name:Labetalol Hydrochloride Impurity 19（(R,S)-Labetalol Hydrochloride）
- CAS Number:81602-14-4
- Molecular formula:C19H25ClN2O3
- Molecular Weight:364.87
2550-26-7
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$9.00/100g
81602-14-4
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Yield:-
Steps:
Multi-step reaction with 6 steps
1: p-TsOH*H2O / benzene / 14 h / Heating
2: NaBH4 / methanol / 16 h / Ambient temperature
4: K2CO3 / dimethylformamide / 4 h / Ambient temperature
5: LiBH4 / benzene; tetrahydrofuran / 2 h / 0 °C
6: H2, 1 N aq. HCl / 20percent Pd(OH)2/C / ethanol / 2 h / 2280 Torr / Ambient temperature
References:
Gold, Elijah H.;Chang, Wei;Cohen, Marvin;Baum, Thomas;Ehrreich, Steward;et al. [Journal of Medicinal Chemistry,1982,vol. 25,# 11,p. 1363 - 1370]
68164-04-5
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81602-14-4
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40187-51-7
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81602-14-4
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83167-23-1
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75637-30-8
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81602-14-4
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