Des(N'-Methyl-2-nitro-1,1-ethenediaMino) N'-Methylureido Nizatidine synthesis

Yield:-

Reaction Conditions:

in acetonitrile;

Steps:

6 Preparation of N-methyl-N'-2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethylthiourea

Following the above reaction sequence, a solution of 0.93 g of 2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethylamine in 10 ml. of anhydrous acetonitrile was prepared. A solution of 0.22 ml. of methyl isocyanate in 5 ml. of anhydrous acetonitrile was added thereto. The reaction was stirred at ambient temperature for about 2.5 hours at which time the solvent was removed by evaporation. The resulting residue slowly crystallized and was recrystallized from cylcohexane to yield about 0.97 g of N-methyl-N'-2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethylurea melting at about 56°-59° C. Analysis: calculated: C, 45.81; H, 6.99; N, 19.42; O, 5.55. found: C, 46.03; H, 6.66; N, 19.41; O, 5.71.

References:

US4382090,1983,A