ChemicalBook CAS DataBase List Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester

Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester synthesis

12synthesis methods

Product Name:Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester
CAS Number:83249-10-9
Molecular formula:C8H10O4
Molecular Weight:170.16

5781-53-3 Synthesis

5781-53-3
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35634-10-7
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Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester

83249-10-9
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$24.00/100mg

Yield:83249-10-9 63%

Reaction Conditions:

Stage #1:monomethyl oxalyl chloride;[1.1.1]propellane in diethyl ether at -80 - 0;
Stage #2: with water for 2 h;Alkaline conditions;

Steps:

3.a (a) 3-(methoxycarbonyl)bicyclo[l.l.l]pentane-l-carboxylic acid (9) using flow system
A solution of [l.l.ljpropellane in Et₂0 2 (500 mL_; 161 mmol, 1 equiv.), and a solution of methyl chlorooxoacetate 3 (16.3 mL, 177 mmol, 1.1 equiv.) in Et₂0 (49.7 mL) were prepared independently. The entire reactor was flushed with pure Et₂0 (pump 1: 4.0 mL-min^-1, pump 2: 0.5 mL-min^-1) for 5 min. The solution of reagent (2) at 0 to -80 °C was then injected at a flow rate of 4.0 mL-min^"1 and the solution of reagent (3) at room temperature was then injected at a flow rate of 0.5 mL-min^-1 to the photoreactor (volume 58 mL; FEP tube was rotated on the lamp) in an ice bath. The reaction mixture was quenched with aqueous basic solution of NaOH, KOH, NaHC03 or KHC03, etc after the solution exits the photoreactor. After 2 h of vigorous stirring, the aqueous layer was separated and acidified until pH = 1. The mixture was then extracted with DCM (3 x 500 mL). The combined organic layers were dried over MgS0₄, filtered and concentrated under reduced pressure to provide 3- (methoxycarbonyl)bicyclo[l.l.l]pentane-l-carboxylic acid (9, 17.5 g, 103 mmol, 63%) as a pale yellow solid

References:

SPIROCHEM AG;SUZUKI, Yoshikazu;JIMENEZ-TEJA, Daniel;SALOMÉ, Christophe;FESSARD, Thomas WO2017/157932, 2017, A1 Location in patent:Page/Page column 27

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