1-(2-fluorobenzyl)-5-oxopyrrolidine-3-carboxylic acid(SALTDATA: FREE) synthesis

3synthesis methods

Product Name:1-(2-fluorobenzyl)-5-oxopyrrolidine-3-carboxylic acid(SALTDATA: FREE)
CAS Number:845546-24-9
Molecular formula:C12H12FNO3
Molecular Weight:237.23

3-Pyrrolidinecarboxylic acid, 1-[(2-fluorophenyl)methyl]-5-oxo-, methyl ester

1171491-08-9
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1-(2-fluorobenzyl)-5-oxopyrrolidine-3-carboxylic acid(SALTDATA: FREE)

845546-24-9
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$106.04/1gm:

Yield:845546-24-9 25 g

Reaction Conditions:

with water;sodium hydroxide in methanol;

Steps:

10.2 Step 2. Synthesis of compound 3

A solution of NaOH (12.0 g, 300 mmol) in water (70 mL), was added to a solution of compound 2 (28.7 g, 98 mmol) in MeOH (200 mL). the resulted mixture was stirred overnight and concentrated under reduced pressure. The residue was acidified with aq.1 M HCl to pH 3-4. The formed precipitate was filtered off, washed with water and dried under deduced pressure to afford compound 3 (25 g, 90%) as a white solid that was used for the next step without further purification.

References:

WO2020/172565,2020,A1 Location in patent:Page/Page column 186

20781-20-8 Synthesis

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845546-24-9
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References

617-52-7 Synthesis

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845546-24-9
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$106.04/1gm:

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