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ChemicalBook CAS DataBase List ethyl 5-hydroxy-2,2-dimethyl-3-oxopentanoate(SALTDATA: FREE)
84752-35-2

ethyl 5-hydroxy-2,2-dimethyl-3-oxopentanoate(SALTDATA: FREE) synthesis

3synthesis methods
-

Yield:84752-35-2 71%

Reaction Conditions:

Stage #1: ethyl 2-bromoisobutyrate;3-Hydroxypropionitrilewith zinc in tetrahydrofuran;Reformatsky-type reaction;
Stage #2: with hydrogenchloride in tetrahydrofuran;

References:

Fuerstner;Mathes;Grela [Chemical Communications,2001,# 12,p. 1057 - 1059]