(2-Chloro-6-methyl-pyrimidin-4-yl)-(5-methyl-3H-pyrazol-3-yl)-amine synthesis
- Product Name:(2-Chloro-6-methyl-pyrimidin-4-yl)-(5-methyl-3H-pyrazol-3-yl)-amine
- CAS Number:851435-28-4
- Molecular formula:C9H10ClN5
- Molecular Weight:223.66
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Yield:851435-28-4 74%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in dimethyl sulfoxide at 60; for 24 h;
Steps:
1.1 first step2-chloro-6-methyl-N- (5-methyl-1H-pyrazol-3-yl) pyrimidin-4-amine
In a 100mL single mouth bottle,Add compound (1a) (9.72 g, 60 mmol),Compound (1b) (7.0 g, 72 mmol),DMSO 30mL and DIPEA (11.6g, 72mmol),The reaction was carried out at 60 ° C for 24 hours.The reaction was monitored by TLC until the raw materials disappeared, the temperature was lowered to room temperature, ethyl acetate (200 mL) was added, washed with water (30 mL × 3), washed with saturated brine once, dried over anhydrous sodium sulfate, filtered, and the solvent was removed under reduced pressure to obtain a brown yellow viscous liquid. .Add 80mL of dichloromethane and let stand for 3 hours.9.9 g of a white solid (1c) was deposited in a yield of 74%.
References:
CN110294745,2019,A Location in patent:Paragraph 0057; 0061-0065
5424-21-5
333 suppliers
$10.00/5g
31230-17-8
365 suppliers
$5.00/5g
851435-28-4
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42779-56-6
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31230-17-8
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851435-28-4
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