ChemicalBook CAS DataBase List Tert-butyl [(1r,2s)-2-ethenyl-1-{[(1-Methylcyclopropyl)sulfonyl]carbaMoyl}cyclopropyl]carbaMate

Tert-butyl [(1r,2s)-2-ethenyl-1-{[(1-Methylcyclopropyl)sulfonyl]carbaMoyl}cyclopropyl]carbaMate synthesis

5synthesis methods

Product Name:Tert-butyl [(1r,2s)-2-ethenyl-1-{[(1-Methylcyclopropyl)sulfonyl]carbaMoyl}cyclopropyl]carbaMate
CAS Number:853269-57-5
Molecular formula:C15H24N2O5S
Molecular Weight:344.43

669008-26-8 Synthesis

1-Methyl-cyclopropanesulfonic acid amide

669008-26-8
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159622-10-3 Synthesis

159622-10-3
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$12.00/250mg

Tert-butyl [(1r,2s)-2-ethenyl-1-{[(1-Methylcyclopropyl)sulfonyl]carbaMoyl}cyclopropyl]carbaMate

853269-57-5
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Yield:853269-57-5 79%

Reaction Conditions:

Stage #1: (1R,2S)-1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylic acidwith 1,1'-carbonyldiimidazole in tetrahydrofuran at 85; for 0.5 h;
Stage #2: 1-methylcyclopropane-1-sulfonamidewith 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran at 20; for 16 h;

Steps:

C.216.1

To a solution of lR-tert-butoxycarbonylamino-2S-vinyl-cyclopropanecarboxylic acid (2.3 g, 10.1 mmol) in THF (40 mL) was added CDI (1.80 g, 11.6 mmol) and was heated to 85 °C for 30 min. After let cool to rt, the reaction mixture was treated with 1-methyl-cyclopropanesulfonam (1.64 g, 12.1 mmol) and DBU (3.08 g, 20.2 mmol). After stirring at rt for 16 h, the reaction was diluted with EtOAc (160 mL) and washed with 2x25 mL IN HC1. The combined aqueous layer was extracted with 1x50 mL EtOAc. The combined organic layer was washed with H20 (50 mL), brine, dried over MgS04 and concentrated to a light yellow solid product (2.75 g, 79%). The product was used as crude. MS m/z 367 (M+Na).

References:

WO2005/51410,2005,A1 Location in patent:Page/Page column 126

159622-10-3 Synthesis

159622-10-3
147 suppliers
$12.00/250mg

853269-57-5
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inquiry

References