3-((4-METHYLPIPERAZIN-1-YL)METHYL)-5-(TRIFLUOROMETHYL)ANILINE synthesis
- Product Name:3-((4-METHYLPIPERAZIN-1-YL)METHYL)-5-(TRIFLUOROMETHYL)ANILINE
- CAS Number:853296-94-3
- Molecular formula:C13H18F3N3
- Molecular Weight:273.3
![Piperazine, 1-methyl-4-[[3-nitro-5-(trifluoromethyl)phenyl]methyl]-](/CAS/20210305/GIF/942076-92-8.gif)
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Yield:853296-94-3 96.1%
Reaction Conditions:
with palladium on activated charcoal in ethanol at 50;Inert atmosphere;
Steps:
23.4 Preparation of 3-((4-methylpiperazin-1-yl) methyl)-5-(trifluoromethyl)
To a solution of 1-methyl-4-(3-nitro-5-(trifluoromethyl) benzyl) piperazine (2.4 g, 7.96 mmol) in 75% ethanol, 10% palladium on carbon (240 mg, 10% eq) was added. The solution afforded was replaced with nitrogen 3 times and the reaction proceeded at 50° C. After completion of the reaction, the solution was filtered under reduced pressure, evaporated to dryness to obtain the desired product as a white solid (2.1 g, 96.1% yield). MS m/z (ESI): 274.1 [M+H].
References:
US2017/305920,2017,A1 Location in patent:Page/Page column 0213
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![[3-NITRO-5-(TRIFLUOROMETHYL)PHENYL]METHANOL](/CAS/GIF/180146-66-1.gif)
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328-80-3
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