4-Thiazolecarboxylicacid,2-(methoxymethyl)-,ethylester(9CI) synthesis
1synthesis methods
- Product Name:4-Thiazolecarboxylicacid,2-(methoxymethyl)-,ethylester(9CI)
- CAS Number:854754-20-4
- Molecular formula:C8H11NO3S
- Molecular Weight:201.24
Yield:854754-20-4 57%
Reaction Conditions:
with magnesium sulfate in acetone; for 16 h;Heating / reflux;
Steps:
6.C
A solution containing the product from Example 6B (7 g, 66.6 mmol) in acetone (270 mL) was treated with ethyl bromopyruvate (8.4 mL, 66.6 mmol) and magnesium sulfate (7.9 g, 66.6 mmol), heated at reflux for 16 hours, cooled to 25° C., filtered and concentrated. The residue was chromatographed on silica gel eluting with chloroform to give the title compound (7.6 g, 57% yield).
References:
US2005/131017,2005,A1 Location in patent:Page/Page column 99