4-iodo-3-methyl-5-(trifluoromethyl)-1H-pyrazole(SALTDATA: FREE) synthesis
- Product Name:4-iodo-3-methyl-5-(trifluoromethyl)-1H-pyrazole(SALTDATA: FREE)
- CAS Number:855343-07-6
- Molecular formula:C5H4F3IN2
- Molecular Weight:276
10010-93-2
225 suppliers
$6.00/100mg
855343-07-6
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$130.00/500mg
Yield:855343-07-6 60.6%
Reaction Conditions:
with ammonium cerium (IV) nitrate;iodine in acetonitrile at 20;
Steps:
12.A 12A. Preparation of 4-iodo-5-methyl-3-(trifluoromethyl)-lH-pyrazole
[0151] To a solution of 5-methyl-3-(trifluoromethyl)-lH-pyrazole (6.0 g, 30 mmol, 1 eq) in CH3CN (60 mL), were added I2 (7.6 g, 30 mmol, 1 eq) and CAN (8.22 g, 15 mmol, 0.5 eq) in one portion. Then the mixture was stirred at room temperature overnight. TLC indicated the reaction was completed. The reaction mixture was poured into ice water and extracted with EtOAc (2x100 mL). The combined organic layers were washed with brine (3x40 mL), aq.Na2S03 (2x30 mL), dried over Na2S04 and concentrated in vacuum to give crude product, which was purified by column chromatography on silica gel to give4-iodo-5-methyl-3- (trifluoromethyl)-lH-pyrazole (5.0 g, yield: 60.6%); LC/MS: m/z (M++l) = 277.
References:
WO2013/6792,2013,A1 Location in patent:Paragraph 0151
367-57-7
291 suppliers
$10.00/2g
855343-07-6
30 suppliers
$130.00/500mg