5-bromo-2-cyclopropylisoindolin-1-oneCAS Registry Number 864866-56-8 Name: 1H-Isoindol-1-one, 5-bromo-2-cyclopropyl-2,3-dihydro- 5-Bromo-2-cyclopropylisoindolin-1-one synthesis
- Product Name:5-bromo-2-cyclopropylisoindolin-1-oneCAS Registry Number 864866-56-8 Name: 1H-Isoindol-1-one, 5-bromo-2-cyclopropyl-2,3-dihydro- 5-Bromo-2-cyclopropylisoindolin-1-one
- CAS Number:864866-56-8
- Molecular formula:C11H10BrNO
- Molecular Weight:252.11
765-30-0
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Yield:864866-56-8 94%
Reaction Conditions:
with potassium carbonate in ethanol at 40; for 3 h;
Steps:
129.2
Step 2 5-bromo-2-cyclopropylisoindoIin-l-one; A mixture of methyl 4-bromo-2-(bromomethyl)benzoate (0.13 g, 0.42 mmol), cyclopropylamine(0.034 mL, 0.49 mmol) and potassium carbonate (0.090 g, 0.65 mmol) in ethanol (0.9 mL) was stirred at 40 0C for 3 h. The reaction mixture was quenched with saturated sodium bicarbonate and extracted with EtOAc (3x20 mL). The combined organic layers were washed with brine, dried over anhydrous NajSO^, filtered, and concentrated. The residue was purified by chromatography on silica gel with 30% EtOAc in hexanes to afford the desired product (0.10 g, 94%). LCMS (M+H)+: m/z = 252.0/254.0.
References:
WO2010/75270,2010,A1 Location in patent:Page/Page column 184
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