TERT-BUTYL 4-(3-BROMOBENZYL)PIPERAZINE-1-CARBOXYLATE synthesis
- Product Name:TERT-BUTYL 4-(3-BROMOBENZYL)PIPERAZINE-1-CARBOXYLATE
- CAS Number:865314-27-8
- Molecular formula:C16H23BrN2O2
- Molecular Weight:355.27
823-78-9
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57260-71-6
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865314-27-8
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Yield:865314-27-8 92%
Reaction Conditions:
with triethylamine in tetrahydrofuran at 20; for 1 h;
Steps:
14a
To a stirred solution of 1-bromo-3-(bromomethyl)benzene (677 mg, 2.71 mmol) in THF (10 ml) was added triethylamine (380 μL, 2.71 mmol), followed by tert-butyl piperazine-1-carboxylate (504 mg, 2.71 mmol). The mixture was allowed to stir at RT for one hour. The solvent was evaporated and the residue was purified with a silica gel column eluting with 1:10 EtOAc/hexanes to give the title compound as an oil (888 mg, 2.49 mmol, 92%). [M+H] calc'd for C16H24BrN2O2, 355; found, 355.
References:
US2006/84650,2006,A1 Location in patent:Page/Page column 92
3132-99-8
477 suppliers
$5.00/10g
57260-71-6
738 suppliers
$5.00/5g
865314-27-8
14 suppliers
$127.00/1g