ChemicalBook CAS DataBase List Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate

Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate synthesis

5synthesis methods

Product Name:Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate
CAS Number:867065-53-0
Molecular formula:C15H23N3O4S
Molecular Weight:341.43

100367-77-9 Synthesis

100367-77-9
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$5.00/250mg

57260-71-6 Synthesis

57260-71-6
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Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate

867065-53-0
44 suppliers
$35.00/100mg

Yield:867065-53-0 88%

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine in 1,4-dioxane at 100;

Steps:

59.1 Step 1:

Tert-butyl piperazine-1-carboxylate (1.8 g, 10 mmol), ethyl 2-bromothiazole-4-carboxylate (2.36 g, 10 mmol) and DIPEA (2.02 g, 20 mmol) were added into 1 ,4-dioxane (15 ml). The mixture was stirred for overnight at 1000 C. When the reaction finished, it was extracted by EA and washed by brine. It was purified by flash column chromatography (PE/EA=5:1-3:1) to afford the yellow solid as product (3.0 g, 88%).

References:

US2018/141923,2018,A1 Location in patent:Paragraph 0599; 0600; 0601