Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate synthesis
- Product Name:Ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-4-carboxylate
- CAS Number:867065-53-0
- Molecular formula:C15H23N3O4S
- Molecular Weight:341.43
100367-77-9
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57260-71-6
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867065-53-0
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Yield:867065-53-0 88%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in 1,4-dioxane at 100;
Steps:
59.1 Step 1:
Tert-butyl piperazine-1-carboxylate (1.8 g, 10 mmol), ethyl 2-bromothiazole-4-carboxylate (2.36 g, 10 mmol) and DIPEA (2.02 g, 20 mmol) were added into 1 ,4-dioxane (15 ml). The mixture was stirred for overnight at 1000 C. When the reaction finished, it was extracted by EA and washed by brine. It was purified by flash column chromatography (PE/EA=5:1-3:1) to afford the yellow solid as product (3.0 g, 88%).
References:
US2018/141923,2018,A1 Location in patent:Paragraph 0599; 0600; 0601
41731-52-6
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57260-71-6
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867065-53-0
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70-23-5
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196811-66-2
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867065-53-0
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$35.00/100mg
81449-93-6
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57260-71-6
749 suppliers
$5.00/5g
867065-53-0
42 suppliers
$35.00/100mg
57260-71-6
749 suppliers
$5.00/5g
867065-53-0
42 suppliers
$35.00/100mg