Pyrazolo[1,5-a]pyrimidine-3-acetamide,N,N-diethyl-2-(4-hydroxyphenyl)-5,7-dimethyl- synthesis
- Product Name:Pyrazolo[1,5-a]pyrimidine-3-acetamide,N,N-diethyl-2-(4-hydroxyphenyl)-5,7-dimethyl-
- CAS Number:868072-17-7
- Molecular formula:C20H24N4O2
- Molecular Weight:352.43
![Pyrazolo[1,5-a]pyrimidine-3-acetamide, N,N-diethyl-5,7-dimethyl-2-[4-(1-methylethoxy)phenyl]-](/CAS/20210305/GIF/1384517-66-1.gif)
1384517-66-1
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868072-17-7
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Yield: 77.1%
Reaction Conditions:
with aluminum (III) chloride in dichloromethane at 30; for 2 h;
Steps:
2.2.6
Step 2-6, add material 11 [Compound 11] (5.268 g, 13.4 mmol, 1.0 eq) and 100 mL of dichloromethane to a 250 mL single-mouth bottle.Anhydrous aluminum trichloride (5.876 g, 44.1 mmol, 3.3 eq) was added portionwise under ice bath. After the addition, the temperature is naturally raised to 30 °C for about 2 h, and the temperature is cooled to about 0 °C. Quenched by adding saturated ammonium chloride solution,After stirring for 30 min, it was extracted with dichloromethane (150 mL*3).Combined drying,After concentration, column chromatography (DCM:MeOH = 30:1).Yield 3.627 g of a white solid (substance 12),1H-NMR (CDCl3) was obtained in a total yield of 77.1%.
References:
The Chinese People's Liberation Army The East War Zone Zong Hospital;Jiangsu Huayi Technology Co., Ltd.;Zhang Longjiang;Xu Zhihong;Gao Feng;Kong Xiang;Yang Guifen;Gui Yuan CN109734720, 2019, A Location in patent:Paragraph 0076; 0078; 0084
![Pyrazolo[1,5-a]pyrimidine-3-acetamide, N,N-diethyl-2-(4-methoxyphenyl)-5,7-dimethyl-](/CAS/20200331/GIF/386297-97-8.gif)
386297-97-8
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868072-17-7
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3672-47-7
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386298-14-2
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386298-19-7
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