
Ethanone, 1-[8-(phenylmethyl)-2,8-diazaspiro[4.5]dec-2-yl]- synthesis
- Product Name:Ethanone, 1-[8-(phenylmethyl)-2,8-diazaspiro[4.5]dec-2-yl]-
- CAS Number:870082-42-1
- Molecular formula:C17H24N2O
- Molecular Weight:272.3853

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![8-BENZYL-2,8-DIAZA-SPIRO[4.5]DECANE](/CAS/GIF/336191-15-2.gif)
336191-15-2
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$58.00/100mg
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870082-42-1
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Yield:870082-42-1 28%
Reaction Conditions:
with pyridine at 20; for 2 h;
Steps:
intermesiate 12A; 1-benzyl-4-spiro-(1-pyrrolidin-3-yl)ethanon)piperidine
To a solution of 1-benzyl-4-spiro-(3-pyrrolidino)piperidine (0.5 g, 2.2 mmol) dissolved in pyridine (5 mL) was added acetyl chloride (0.17 mL, 2.4 mmol). The mixture was stirred at room temperature for 2 hours then concentrated. The residue was partitioned between ethyl acetate and water. The organic phase was washed with water, then brine, dried (Na2SO4), filtered, and concentrated to provide the desired product as a brown oil (0.168 g, 28% yield). 1H NMR (300 MHz, CDCl3) δ 7.30-7.19 (5H, m), 3.51-3.42 (4H, m), 3.29-3.16 (2H, m), 2.59-2.21 (4H, m), 2.00 (3H, s), 180-1.67 (2H, m), 1.58-1.52 (4H, m). LCMS (M+H) calcd for C17H25N2O: 273.19; found: 273.31.
References:
US2005/261322,2005,A1 Location in patent:Page/Page column 24