Benzenemethanamine, .alpha.-methyl-4-(1H-pyrazol-1-yl)-, (.alpha.R)- synthesis

Yield:871721-01-6 84%

Reaction Conditions:

with methanol;lithium hydroxide

References:

Li, Dansu;Popovici-Muller, Janeta;Belanger, David B.;Caldwell, John;Dai, Chaoyang;David, Maria;Girijavallabhan, Vinay M.;Lavey, Brian J.;Lee, Joe F.;Liu, Zhidan;Mazzola, Rob;Rizvi, Razia;Rosner, Kristin E.;Shankar, Bandarpalle;Spitler, Jim;Ting, Pauline C.;Vaccaro, Henry;Yu, Wensheng;Zhou, Guowei;Zhu, Zhaoning;Niu, Xiaoda;Sun, Jing;Guo, Zhuyan;Orth, Peter;Chen, Shiying;Kozlowski, Joseph A.;Lundell, Daniel J.;Madison, Vincent;McKittrick, Brian;Piwinski, John J.;Shih, Neng-Yang;Shipps Jr., Gerald W.;Siddiqui, M. Arshad;Strickland, Corey O. [Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,# 16,p. 4812 - 4815] Location in patent:scheme or table