3-PYRIDINECARBOXAMIDE, N-(1,1-DIMETHYLETHYL)-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- synthesis
- Product Name:3-PYRIDINECARBOXAMIDE, N-(1,1-DIMETHYLETHYL)-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-
- CAS Number:881743-64-2
- Molecular formula:C22H30N4O
- Molecular Weight:366.5
109-01-3
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Yield: 84%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in isopropyl alcoholReflux;
Steps:
1 Synthesis of intermediate A-3
Take intermediate A-2 (1 eq) in 10 ml of isopropanol.N-methylpiperazine (1.2 eq) and DIEA (N,N-diisopropylethylamine) (1.5 eq). Raise to reflux and continue to react for 6-8 hours.The solvent was distilled off under reduced pressure to give a crude oil.Pure product separated by silica gel column chromatography,The yield was 84%.
References:
Beijing Kuanhou Pharmaceutical Technology Co., Ltd.;Cui Yimin;He Long;Ouyang Liang;Gou Maling;Wang Ling CN109384712, 2019, A Location in patent:Paragraph 0107; 0109; 0116; 0117
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