N-((1r,4r)-4-(4-(cyclopropylMethyl)piperazin-1-yl)cyclohexyl)acetaMide synthesis

1synthesis methods

Product Name:N-((1r,4r)-4-(4-(cyclopropylMethyl)piperazin-1-yl)cyclohexyl)acetaMide
CAS Number:882660-40-4
Molecular formula:C16H29N3O
Molecular Weight:279.42

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57184-25-5 Synthesis

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N-((1r,4r)-4-(4-(cyclopropylMethyl)piperazin-1-yl)cyclohexyl)acetaMide

882660-40-4
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Yield:882660-40-4 56.1%

Reaction Conditions:

Stage #1: N-(2-oxocyclohexyl)acetamide;1-cyclopropylmethylpiperazine in toluene;Reflux;
Stage #2: with platinum(IV) oxide;hydrogen in ethanol at 50; under 2585.81 Torr;

References:

US2012/238754,2012,A1 Location in patent:Paragraph 0094; 0095; 0096; 0097; 0098