(3-((3-(trifluoroMethyl)phenyl)carbaMoyl)phenyl)boronic acid synthesis
- Product Name:(3-((3-(trifluoroMethyl)phenyl)carbaMoyl)phenyl)boronic acid
- CAS Number:882678-73-1
- Molecular formula:C14H11BF3NO3
- Molecular Weight:309.05
349117-57-3
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882678-73-1
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Yield:882678-73-1 82%
Reaction Conditions:
Stage #1: 3-iodo-N-(3-(trifluoromethyl)phenyl)benzamidewith methylmagnesium chloride in tetrahydrofuran at 0; for 0.75 h;
Stage #2: with tert.-butyl lithium in tetrahydrofuran;pentane at -78; for 0.0833333 h;
Stage #3: with Trimethyl borate in tetrahydrofuran;pentane;
References:
DiMauro, Erin F.;Newcomb, John;Nunes, Joseph J.;Bemis, Jean E.;Boucher, Christina;Buchanan, John L.;Buckner, William H.;Cee, Victor J.;Chai, Lilly;Deak, Holly L.;Epstein, Linda F.;Faust, Ted;Gallant, Paul;Geuns-Meyer, Stephanie D.;Gore, Anu;Gu, Yan;Henkle, Brad;Hodous, Brian L.;Hsieh, Faye;Huang, Xin;Kim, Joseph L.;Lee, Josie H.;Martin, Matthew W.;Masse, Craig E.;McGowan, David C.;Metz, Daniela;Mohn, Deanna;Morgenstern, Kurt A.;Oliveira-Dos-Santos, Antonio;Patel, Vinod F.;Powers, David;Rose, Paul E.;Schneider, Stephen;Tomlinson, Susan A.;Tudor, Yan-Yan;Turci, Susan M.;Welcher, Andrew A.;White, Ryan D.;Zhao, Huilin;Zhu, Li;Zhu, Xiaotian [Journal of Medicinal Chemistry,2006,vol. 49,# 19,p. 5671 - 5686]
1711-10-0
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882678-73-1
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618-51-9
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882678-73-1
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