
5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER synthesis
- Product Name:5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
- CAS Number:885276-93-7
- Molecular formula:C10H9BrN2O2
- Molecular Weight:269.09

1533440-88-8
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623-47-2
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885276-93-7
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$36.00/100mg
Yield:885276-93-7 300 mg
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide; for 0.166667 h;
Steps:
1 Compound 64.3. Ethyl 5-bromopyrazolo[l,5-a]pyridine-3-carboxylate
Compound 64.3. Ethyl 5-bromopyrazolo[l,5-a]pyridine-3-carboxylate. Into a 250-mL three neck round-bottom flask, was placed a solution of l-amino-4-bromopyridin-l- ium iodide (compound 64.2, 15 g, -50% purity, 24.9 mmol) in N.N-dimethylformamide (80 mL). Potassium carbonate (10.6 g, 76.7 mmol) was added portion-wise followed by the addition of ethyl propiolate (1 1.7 mL, 1 15 mmol) drop-wise over 10 min. The resulting mixture was stirred overnight at room temperature, then diluted with EtOAc (300 mL) and water (100 mL). The solids were removed by filtration and the organic layer was washed with brine (3 x 50 mL), dried (Na2S04), filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether (1 : 10) as the eluent to yield the title compound as a brown solid (300 mg, 6%).
References:
WO2014/8197,2014,A1 Location in patent:Page/Page column 135

1120-87-2
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623-47-2
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![5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/885276-93-7.gif)
885276-93-7
125 suppliers
$36.00/100mg
![ethyl 5-((tert-butoxycarbonyl)aMino)pyrazolo[1,5-a]pyridine-3-carboxylate](/CAS/GIF/1101120-33-5.gif)
1101120-33-5
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$45.00/10mg
![5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/885276-93-7.gif)
885276-93-7
125 suppliers
$36.00/100mg

1060814-91-6
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$65.00/10mg
![5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/885276-93-7.gif)
885276-93-7
125 suppliers
$36.00/100mg

98400-69-2
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$6.00/1g
![5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/885276-93-7.gif)
885276-93-7
125 suppliers
$36.00/100mg