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890839-10-8

methyl 2-methyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propanoate synthesis

5synthesis methods
-

Yield:890839-10-8 95 %

Steps:

P.54.1 Step 1:

Step 1:
Methyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate
The desired product was obtained in a similar manner to Step 1 of Preparation Example 53 by using methyl 2-(4-bromophenyl)-2-methylpropanoate (1 g, 3.89 mmol).
(Yield 95%)
1H-NMR (CHLOROFORM-D) δ 7.80 (d, J = 8.2 Hz, 2H), 7.39-7.31 (m, 2H), 3.74-3.59 (m, 3H), 1.60 (s, 6H), 1.37-1.32 (m, 12H)

References:

EP4071147,2022,A1