9-Azabicyclo(3.3.1)nonan-3-one Hydrochloride synthesis
- Product Name:9-Azabicyclo(3.3.1)nonan-3-one Hydrochloride
- CAS Number:72761-60-5
- Molecular formula:C8H13NO.HCl
- Molecular Weight:0
![9-Methyl-9-azabicyclo[3.3.1]nonan-3-one](/CAS/GIF/552-70-5.gif)
552-70-5
136 suppliers
$21.00/250mg
72761-60-5
56 suppliers
$24.00/250mg
Yield:72761-60-5 68%
Reaction Conditions:
Stage #1: pseudopelletierinewith carbonochloridic acid 1-chloro-ethyl ester in toluene at 20 - 90; for 44 h;
Stage #2: with methanol for 2 h;Reflux;
Steps:
A
1 -Chloroethylchloroformate (21.4 g, 150 mmol) was added to a mixture of 9- methyl-9-aza-bicyclo[3.3.1]nonan-3-one (15.3 g, 100 mmol) and toluene (100 ml) and was allowed to stir at room-temperature for 15 h. The mixture was stirred at 90°C for 9 h. Another portion of 1 -chloroethylchloroformate (14.3 g, 100 mmol) was added followed by stirring at 90°C for 20 h. Methanol (80 ml) was added fol- lowed by reflux for 2 h. The mixture was cooled on an ice-bath. The pure product precipitated, was filtered and washed with diethylether. Yield 12.0 g (68%).
References:
WO2009/98209,2009,A1 Location in patent:Page/Page column 16
![N-Boc-9-azabicyclo[3.3.1]nonan-3-one](/CAS/GIF/512822-27-4.gif)
512822-27-4
104 suppliers
$9.00/250mg
72761-60-5
56 suppliers
$24.00/250mg