ChemicalBook CAS DataBase List 2-ACETAMIDOPYRIDINE-5-BORONIC ACID PINACOL ESTER, 97%

2-ACETAMIDOPYRIDINE-5-BORONIC ACID PINACOL ESTER, 97% synthesis

6synthesis methods

Product Name:2-ACETAMIDOPYRIDINE-5-BORONIC ACID PINACOL ESTER, 97%
CAS Number:904326-87-0
Molecular formula:C13H19BN2O3
Molecular Weight:262.11

7169-97-3 Synthesis

7169-97-3
161 suppliers
$9.00/1g

73183-34-3
555 suppliers
$6.00/5g

2-ACETAMIDOPYRIDINE-5-BORONIC ACID PINACOL ESTER, 97%

904326-87-0
80 suppliers
$55.00/250 mg

Yield: 89.1%

Reaction Conditions:

with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium acetate in 1,4-dioxane at 100;Inert atmosphere;Industrial scale;

Steps:

2.2 Step 2 Preparation of 2-acetylaminopyridine-5-boronic acid pinacol ester:
A 1 L four-necked flask equipped with a magnetic stirrer, a thermometer, a reflux condenser and a bubbler was charged56.41 g (0.264 mol) of 2-acetylamino-5-bromopyridine, 66.02 g (0.26 mol) of bis (pinacolato) diboron and 76.44 g450 mL of dioxane was added and stirred, 1.90 g (0.002589 mol) of ferrocenepalladium chloride was added under the protection of nitrogen, and the mixture was heated to 100 ° C. for 18 to 24 hours,TLC control to the end of the reaction, the temperature was precipitated solids, beating filtration, methanol was added 500mL dissolved, filtered and evaporated to dryness, plus heptane beating, to give the product 60.08g, yield 89.1%.

References:

Dalian Lianhua Chemical Co., Ltd.;Li Xin;Zheng Peng CN103601745, 2017, B Location in patent:Paragraph 0031; 0032

827614-64-2 Synthesis