3-(4-AMINO-PHENYL)-ISOXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER synthesis
- Product Name:3-(4-AMINO-PHENYL)-ISOXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
- CAS Number:908802-68-6
- Molecular formula:C12H12N2O3
- Molecular Weight:232.24
159670-70-9
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Yield:908802-68-6 82%
Reaction Conditions:
with stannous chloride dihydrate;potassium carbonate in ethyl acetate; for 6 h;Reflux;
Steps:
1.3 synthesis of 5- (4-amino-phenyl) isoxazole-3-carboxylate (c)
To the reaction flask was added the compound b (26.2g, 0.1mol), ethyl acetate 300ml, Dissolved under reflux, was added stannous chloride dihydrate (90g, 0.4mol), clarification of the red, reflux 6H, cooled to room temperature, aqueous potassium carbonate was added thereto 300ml (75g potassium carbonate), with ethyl Ethyl extracted three times, spin dry, recrystallized from ethyl acetate to give a yellow solid 5- (4-amino-benzene Yl) isoxazole-3-carboxylate (c) 19g. Yield 82%.
References:
CN104119287,2016,B Location in patent:Paragraph 0060-0061
908581-03-3
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100-19-6
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$5.00/5g
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