Ethyl 5-benzyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-carboxylate synthesis
- Product Name:Ethyl 5-benzyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-carboxylate
- CAS Number:912635-60-0
- Molecular formula:C15H17N3O2
- Molecular Weight:271.31
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Yield:912635-60-0 38.6 %
Reaction Conditions:
with hydrazine hydrate;acetic acid at 110;
Steps:
4.2 second step 5-Benzyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-carboxylic acid ethyl ester 4c
Compound 4b (2.1g, 7.62mmol) was dissolved in the solvent acetic acid (60mL), hydrazine hydrate (539.1mg, 9.15mmol, 85% purity) was added, heated to 110°C for 5 hours, the reaction solution was concentrated under reduced pressure and then added with water Dilute, adjust the pH to about 8 with 2N sodium hydroxide, extract with ethyl acetate (50mL×3), combine the organic phases, dry with anhydrous sodium sulfate, filter to remove the desiccant, and concentrate the filtrate under reduced pressure. Purification by chromatography with eluent system A afforded the title compound 4c (800 mg, yield: 38.6%).
References:
CN115403595,2022,A Location in patent:Paragraph 0340-0343; 0348-0351
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