6-(4-FLUOROPHENYL)-3-METHYLIMIDAZO[2,1-B]THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER synthesis
- Product Name:6-(4-FLUOROPHENYL)-3-METHYLIMIDAZO[2,1-B]THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER
- CAS Number:914204-71-0
- Molecular formula:C15H13FN2O2S
- Molecular Weight:304.34
Yield:914204-71-0 91%
Reaction Conditions:
with polyethylene glycol (PEG-400) in water; for 0.116667 h;Microwave irradiation;Green chemistry;
Steps:
General procedure for synthesis of imidazo[2,1-b]thiazoles 3-20
To stirred solution of polyethylene glycol (PEG-400) (2 mL) in water (2 mL) were added 1-(2-amino-4-methylthiazol-5-yl)ethanone (2 mmol)/ethyl 2-amino-4-methylthiazole-5-carboxylate (2 mmol) and α-bromo aralkyl ketones (phenacyl bromides) (2 mmol), and the mixture was heated at 90 °C or subject to microwave irradiation at 300 W, until reaction completion as indicated by TLC. After reaction completion, the reaction mixture was cooled at room temperature, and the solid product formed was collected by filtration, washed with water, and recrystallized from ethanol to give pure product. The recovered PEG with water was reused for five further cycles.
References:
Vekariya, Rajesh H.;Patel, Kinjal D.;Vekariya, Mayur K.;Prajapati, Neelam P.;Rajani, Dhanji P.;Rajani, Smita D.;Patel, Hitesh D. [Research on Chemical Intermediates,2017,vol. 43,# 11,p. 6207 - 6231]
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