2-BENZYL-4-METHYL-PYRROLO(3,4-C)QUINOLINE-1,3-DIONE synthesis

4synthesis methods

Product Name:2-BENZYL-4-METHYL-PYRROLO(3,4-C)QUINOLINE-1,3-DIONE
CAS Number:91680-07-8
Molecular formula:C19H14N2O2
Molecular Weight:302.33

2623-33-8
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91-56-5 Synthesis

91-56-5
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2-BENZYL-4-METHYL-PYRROLO(3,4-C)QUINOLINE-1,3-DIONE

91680-07-8
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$28.60/10mg

Yield:91680-07-8 35%

Reaction Conditions:

with ethylenediaminediacetic acid in toluene; for 12 h;Reflux;Knoevenagel Condensation;

Steps:

2.35 Various pyrrolo[3,4-c]quinoline-1,3-dione derivative

General procedure: Isatin having various substituents on the benzene ring reacting with β-ketoamide to synthesis pyrrolo[3,4-c]quinoline-1,3-dione derivative by the method of sharing electrons to isatin. Derivative was synthesized by the method. isatin 1.1 mmol was dissolved in 8mL of toluene, β- keto-amide 1.1 mmol, Ethylenediamine diacetate (EDDA) 8 mg, 0.1 mmol was added at room temperature. The reaction mixture was reflux for 4-12 hours and TLC (hexanes / EtOAc, 6: 1, v / v) and evaporation of the solvent when the desired reaction is complete, the remaining residue is hexane on silica gel / EtOAc (4: 1, v / v) of the flash column pyrrolo [3,4-c] quinoline-1,3-solid compound of the purified through chromatography using a variety of brown to give a derivative ions.

References:

KR101528192,2015,B1 Location in patent:Paragraph 0053; 0057; 0071-0074; 0312-0317

Ethanimidothioic acid, N-[2-[2,5-dioxo-1-(phenylmethyl)-3-pyrrolidinyl]phenyl]-, ethyl ester

91680-16-9
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91680-07-8
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References

Ethanimidic acid, N-[2-[2,5-dioxo-1-(phenylmethyl)-3-pyrrolidinyl]phenyl]-, methyl ester

91680-15-8
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91680-07-8
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References

Furo[3,4-c]quinoline-1,3-dione, 4-methyl-

75353-75-2
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100-46-9 Synthesis

100-46-9
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91680-07-8
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References