![](/CAS/20210111/GIF/943847-20-9.gif)
methyl 4-[(hydroxyimino)methyl]-1-naphthalenecarboxylate synthesis
- Product Name:methyl 4-[(hydroxyimino)methyl]-1-naphthalenecarboxylate
- CAS Number:943847-20-9
- Molecular formula:C13H11NO3
- Molecular Weight:229.23
![METHYL 4-FORMYL-1-NAPHTHOATE](/CAS/20180601/GIF/62855-40-7.gif)
62855-40-7
21 suppliers
inquiry
![methyl 4-[(hydroxyimino)methyl]-1-naphthalenecarboxylate](/CAS/20210111/GIF/943847-20-9.gif)
943847-20-9
5 suppliers
inquiry
Yield:943847-20-9 55%
Reaction Conditions:
with hydroxylamine hydrochloride in ethanol;water at 45; for 18 h;
Steps:
4
Preparation 4: (E/Z)-methyl 4-((hydroxyimino)methyl)-1-naphthoate To a solution of methyl 4-formyl-1-naphthoate (Preparation 3, 3.1 g, 14.5 mmol) in ethanol (125 mL) was added NH2OH.NCl (2.05 g, 29 mmol) and water (20 mL). The solution was heated to 45° C. for 18 hours. The reaction was cooled and concentrated under vacuum to remove ethanol. Water (100 mL) was added to the residue and extracted with CH2Cl2 (2×125 mL). The combined organic phases were dried (Na2SO4) and concentrated under vacuum. The crude intermediate was purified by chromatography on silica gel eluting from 100% heptane to 50:50 EtOAc:heptane to afford a solid (1.82 g, 55%). MS m/z (Cl) 230 [M+H]+.
References:
US2012/77765,2012,A1 Location in patent:Page/Page column 15
![Methyl 4-bromo-1-naphthoate](/CAS/GIF/35615-97-5.gif)
35615-97-5
55 suppliers
$28.00/1g
![methyl 4-[(hydroxyimino)methyl]-1-naphthalenecarboxylate](/CAS/20210111/GIF/943847-20-9.gif)
943847-20-9
5 suppliers
inquiry
![4-BROMO-1-NAPHTALENECARBOXYLIC ACID](/CAS/GIF/16650-55-8.gif)
16650-55-8
153 suppliers
$12.00/1g
![methyl 4-[(hydroxyimino)methyl]-1-naphthalenecarboxylate](/CAS/20210111/GIF/943847-20-9.gif)
943847-20-9
5 suppliers
inquiry
![4-METHYL-1-NAPHTHOIC ACID](/CAS/GIF/4488-40-8.gif)
4488-40-8
137 suppliers
$20.50/0.5g
![methyl 4-[(hydroxyimino)methyl]-1-naphthalenecarboxylate](/CAS/20210111/GIF/943847-20-9.gif)
943847-20-9
5 suppliers
inquiry
![methyl 4-methyl-1-naphthoate](/CAS/20180703/GIF/35615-98-6.gif)
35615-98-6
13 suppliers
inquiry
![methyl 4-[(hydroxyimino)methyl]-1-naphthalenecarboxylate](/CAS/20210111/GIF/943847-20-9.gif)
943847-20-9
5 suppliers
inquiry