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4H-Cyclopentapyrimidin-4-one, 2,3-diamino-3,5,6,7-tetrahydro- (9CI) synthesis

2synthesis methods
-

Yield:95095-59-3 10%

Reaction Conditions:

Stage #1: aminoguanidine hydrogen carbonatewith natrium in ethanol at 90; for 0.5 h;Inert atmosphere;
Stage #2: cyclopentyl-2-carboxylic acid ethyl ester in ethanol at 90; for 15 h;Inert atmosphere;

References:

Sishtla, Kamakshi;Lambert-Cheatham, Nathan;Lee, Bit;Han, Duk Hee;Park, Jaehui;Sardar Pasha, Sheik Pran Babu;Lee, Sanha;Kwon, Sangil;Muniyandi, Anbukkarasi;Park, Bomina;Odell, Noa;Waller, Sydney;Park, Il Yeong;Lee, Soo Jae;Seo, Seung-Yong;Corson, Timothy W. [Cell Chemical Biology,2022,vol. 29,# 6,p. 1010 - 14,1023]