5,6-Dihydro-4H-cyclopenta[b]-thiophene-2-carbaldehyde synthesis
- Product Name:5,6-Dihydro-4H-cyclopenta[b]-thiophene-2-carbaldehyde
- CAS Number:956010-59-6
- Molecular formula:C8H8OS
- Molecular Weight:152.21
![4H-Cyclopenta[b]thiophene-2-carboxamide, 5,6-dihydro-N-methoxy-N-methyl-](/CAS/20210305/GIF/1342217-76-8.gif)
1342217-76-8
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956010-59-6
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Yield:956010-59-6 92.1%
Reaction Conditions:
with lithium aluminium tetrahydride in tetrahydrofuran at -75 - 25; for 1 h;
Steps:
38.2 Step 2
A suspension of the compound 28b (3.0 g, 14.2mmol) in THF (150 mL) was added LiAlH4 (0.89 g, 22 mmol) under -75 °C. After then, the temperature was rebound to 25 °C for 1 hour. The mixture was pouring to water, extracted with ethyl acetate. The organic layer was washed with water, brine and dried over Na2S04, concentrated in vacuo to provide compound 28c (2.0 g, 92.1% yield)
References:
WO2014/110688,2014,A1 Location in patent:Page/Page column 103
![5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-2-CARBOXYLIC ACID](/CAS/GIF/40133-06-0.gif)
40133-06-0
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956010-59-6
23 suppliers
$39.00/100mg