[(2S,6R)-6-{N2-Isobutyryl-guanin-9-yl}-4-tritylmorpholin-2-yl]methyl Dimethylphosphoramide Chloridate synthesis
1synthesis methods
- Product Name:[(2S,6R)-6-{N2-Isobutyryl-guanin-9-yl}-4-tritylmorpholin-2-yl]methyl Dimethylphosphoramide Chloridate
- CAS Number:956139-25-6
- Molecular formula:C35H39ClN7O5P
- Molecular Weight:704.15
Yield: 56%
Reaction Conditions:
Stage #1:N-isobutyryl-7-hydroxy-N-trityl morpholinoguanosine with 1,8-diazabicyclo[5.4.0]undec-7-ene;lithium bromide in dichloromethane;acetonitrile at 0; for 0.0333333 h;Inert atmosphere;
Stage #2:N,N-dimethylphosphoroamidic dichloride in dichloromethane;acetonitrile at 0; for 0.333333 h;Inert atmosphere;
References:
Pattanayak, Sankha;Sinha, Surajit [Tetrahedron Letters,2012,vol. 53,# 49,p. 6714 - 6717]