(S)-3-AMINO-5-METHYL-2,3-DIHYDROBENZO[B][1,4]OXAZEPIN-4(5H)-ONE HCL synthesis
- Product Name:(S)-3-AMINO-5-METHYL-2,3-DIHYDROBENZO[B][1,4]OXAZEPIN-4(5H)-ONE HCL
- CAS Number:958488-72-7
- Molecular formula:C10H13ClN2O2
- Molecular Weight:228.6754
1493-27-2
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958488-72-7
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Yield:-
Steps:
Multi-step reaction with 5 steps
1: sodium hydride / N,N-dimethyl-formamide
2: hydrogen; palladium on activated charcoal / methanol / 20 °C
3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C
4: caesium carbonate / N,N-dimethyl-formamide
5: hydrogenchloride
References:
Harris, Philip A.;Marinis, Jill M.;Lich, John D.;Berger, Scott B.;Chirala, Anirudh;Cox, Julie A.;Eidam, Patrick M.;Finger, Joshua N.;Gough, Peter J.;Jeong, Jae U.;Kang, James;Kasparcova, Viera;Leister, Lara K.;Mahajan, Mukesh K.;Miller, George;Nagilla, Rakesh;Ouellette, Michael T.;Reilly, Michael A.;Rendina, Alan R.;Rivera, Elizabeth J.;Sun, Helen H.;Thorpe, James H.;Totoritis, Rachel D.;Wang, Wei;Wu, Dongling;Zhang, Daohua;Bertin, John;Marquis, Robert W. [ACS Medicinal Chemistry Letters,2019,vol. 10,# 6,p. 857 - 862]
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