Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

(S)-3-AMINO-5-METHYL-2,3-DIHYDROBENZO[B][1,4]OXAZEPIN-4(5H)-ONE HCL synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 5 steps
1: sodium hydride / N,N-dimethyl-formamide
2: hydrogen; palladium on activated charcoal / methanol / 20 °C
3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C
4: caesium carbonate / N,N-dimethyl-formamide
5: hydrogenchloride

References:

Harris, Philip A.;Marinis, Jill M.;Lich, John D.;Berger, Scott B.;Chirala, Anirudh;Cox, Julie A.;Eidam, Patrick M.;Finger, Joshua N.;Gough, Peter J.;Jeong, Jae U.;Kang, James;Kasparcova, Viera;Leister, Lara K.;Mahajan, Mukesh K.;Miller, George;Nagilla, Rakesh;Ouellette, Michael T.;Reilly, Michael A.;Rendina, Alan R.;Rivera, Elizabeth J.;Sun, Helen H.;Thorpe, James H.;Totoritis, Rachel D.;Wang, Wei;Wu, Dongling;Zhang, Daohua;Bertin, John;Marquis, Robert W. [ACS Medicinal Chemistry Letters,2019,vol. 10,# 6,p. 857 - 862]