3-(trifluoroMethyl)-5,6,7,8-tetrahydroiMidazo[1,5-a]pyrazine synthesis
- Product Name:3-(trifluoroMethyl)-5,6,7,8-tetrahydroiMidazo[1,5-a]pyrazine
- CAS Number:959238-29-0
- Molecular formula:C7H8F3N3
- Molecular Weight:191.15
![3-(trifluoroMethyl)iMidazo[1,5-a]pyrazine](/CAS/20150408/GIF/CB72728781.gif)
959238-36-9
34 suppliers
$330.00/500mg
959238-29-0
37 suppliers
$265.00/50mg
Yield:959238-29-0 99%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in ethanol at 20;
Steps:
1.9 3-Trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine
3-Trifluoromethyl-imidazo[1,5-a]pyrazine 1j (12.0 g, 64.2 mmol) was dissolved in 150 mL of anhydrous ethanol under stirring, then 10% Pd/C (500 mg) was added to the solution. The reaction mixture was stirred at room temperature under a hydrogen atmosphere overnight. The reaction solution was filtered through a pad of coarse silica gel and concentrated under reduced pressure to obtain the title compound 3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine 1k (12.2 g, yield 99%) as a brown solid. 1H NMR (400 MHz, CDCl3): δ 6.84 (s, 1H), 4.10 (m, 4H), 3.26 (m, 2H), 1.81 (s, 1H)
References:
EP2230241,2010,A1 Location in patent:Page/Page column 19
19847-12-2
356 suppliers
$6.00/5g
959238-29-0
37 suppliers
$265.00/50mg
20010-99-5
169 suppliers
$11.00/1g
959238-29-0
37 suppliers
$265.00/50mg